Artificial enzyme Totally Explained

Everything about Artificial Enzyme totally explained

An artificial enzyme is a synthetic, organic molecule prepared to recreate the active site of an enzyme. Enzyme catalysis of chemical reactions occur with high selectivity and rate in a small part of the enzyme macromolecule known as the active site. There, the binding of a substrate close to functional groups in the enzyme causes catalysis by so-called proximity effects. It is therefore possible to create similar catalysts from small molecule mimics of enzyme active sites by combining, in a small molecule, the ability to bind substrate with catalytic functional groups. Since the artificial enzymes need to bind molecules, they're made based on a host-molecule such as a cyclodextrin, crown ethers or calixarene etc.
A number of artificial enzymes have been reported catalysing various reactions with rate increases up to 10³; this is nevertheless substantially lower than natural enzymes that typically causes rate increases above 10⁶. One of the pioneers in artificial enzyme reasearch is chemist Ronald Breslow.
New approaches based on amino acids or peptides as characteristic molecular moieties have led to a significant expansion of the field of artificial enzymes or enzyme mimics. For instance, recent results by the group of Rob Liskamp(External Link

) have shown that scaffolded histidine residues can be used as mimics of certain metalloproteins and -enzymes. Especially the structural mimicry of certain copper proteins (for example hemocyanin, tyrosinase and catechol oxidase), containing so-called type-3 copper binding sites, has been shown. This is a significant improvement since the use of scaffolded histidine residues is one step closer to the mimicry of enzymes by biological relevant species such as amino acids and peptides(External Link

Further Information

Get more info on 'Artificial Enzyme'.

External Link Exchanges

Do you know how hard it is to get a link from a large encyclopaedia? Well we're different and will prove it. To get a link from us just add the following HTML to your site on a relevant page:

<a href="http://artificial_enzyme.totallyexplained.com">Artificial enzyme Totally Explained</a>

Then simply click through this link from your web page. Our crawlers will verify your link, extract the title of your web page and instantly add a link back to it. If you like you can remove the words Totally Explained and embed the link in article text.
As long as your link remains in place, we'll keep our link to you right here. Please play fair - our crawlers are watching. Your site must be closely related to this one's topic. Any kind of spamming, dubious practises or removing the link will result in your link from us being dropped and, potentially, your whole site being banned.